英文名稱: RNF111 Antigen (Recombinant Protein)
別 名: ring finger protein 111; ARK; hRNF111
儲 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述
Full name: |
ring finger protein 111 |
Synonyms: |
ARK; hRNF111 |
Swissprot: |
Q6ZNA4 |
Gene Accession: |
BC010369 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |