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  • 產(chǎn)品名稱：CD274 抗原

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：350
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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簡單介紹：
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詳情介紹：

中文名稱： CD274 抗原 

英文名稱： CD274 Antigen

相關類別： 抗原

儲     存：  冷凍（-20℃） 

概     述

Synthetic peptide corresponding to a region derived from 70-84 amino acids of human CD274 molecule

技術(shù)規(guī)格

Full name

CD274 molecule

Synonyms

B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1

Swissprot

Q9NZQ7

Gene Accession

NP_054862

Background

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.





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