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  • 產品名稱：NELFA 抗原（重組蛋白）

  • 產品型號：1mg
  • 產品廠商：通蔚生物
  • 產品價格：3580
  • 產品庫存：35
  • 產品文檔：
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詳情介紹：


中文名稱： NELFA 抗原（重組蛋白）

英文名稱： NELFA Antigen (Recombinant Protein)

別      名： negative elongation factor complex member A; WHSC2; NELF-A; P/OKcl.15

相關類別： 抗原

儲      存： 冷凍（-20℃） 

概      述

Fusion protein corresponding to a region derived from 329-528 amino acids of human NELFA

技術規(guī)格

Full name:

negative elongation factor complex member A

Synonyms:

WHSC2; NELF-A; P/OKcl.15

Swissprot:

Q9H3P2

Gene Accession:

BC002764

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene is expressed ubiquitously with higher levels in fetal than in ***** tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.





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