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  • 產(chǎn)品名稱：DLAT 抗原（重組蛋白）

  • 產(chǎn)品型號：100ug
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：800
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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簡單介紹：
DLAT 抗原（重組蛋白）深獲顧客信賴外，更帶給顧客喜悅和滿足，公司員工亦因此找到工作及生活的意義，將緊跟經(jīng)營管理和科學(xué)技術(shù)發(fā)展的步伐，提升和加強(qiáng)公司的市場競爭力，同心協(xié)力，盡展創(chuàng)意，致力于可持續(xù)發(fā)展、向社會(huì)盡責(zé)的企業(yè)宗旨。
詳情介紹：
中文名稱： DLAT 抗原（重組蛋白）

英文名稱： DLAT Antigen (Recombinant Protein)

別     名：  dihydrolipoamide S-acetyltransferase; DLTA; PDCE2; PDC-E2

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to C terminal 200 amino acids of human DLAT

技術(shù)規(guī)格

Full name:

dihydrolipoamide S-acetyltransferase

Synonyms:

DLTA; PDCE2; PDC-E2

Swissprot:

P10515

Gene Accession:

BC039084

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.






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