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  • 產(chǎn)品名稱(chēng):CCM2 抗原(重組蛋白)

  • 產(chǎn)品型號(hào):1mg
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詳情介紹:

中文名稱(chēng): CCM2 抗原(重組蛋白)

英文名稱(chēng): CCM2 Antigen (Recombinant Protein)

別      名: CCM2 scaffolding protein; OSM; C7orf22; PP10187

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類(lèi)別: 抗原

概     述

Fusion protein corresponding to a region derived from 245-444 amino acids of human CCM2

技術(shù)規(guī)格

Full name:

CCM2 scaffolding protein

Synonyms:

OSM; C7orf22; PP10187

Swissprot:

Q9BSQ5

Gene Accession:

BC004903

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.





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