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  • 產(chǎn)品名稱:兔抗PTPN6(Ab564) 多克隆抗體

  • 產(chǎn)品型號:100ul
  • 產(chǎn)品廠商:通蔚生物
  • 產(chǎn)品價格:1560
  • 產(chǎn)品庫存:60
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兔抗PTPN6(Ab-564) 多克隆抗體長期為國內(nèi)科研機構(gòu)、高校和科研人員提供上等產(chǎn)品,在廣大用戶的幫助和支持下,經(jīng)過不懈的努力,已成為國內(nèi)生命科學領域產(chǎn)品的主要供應商之一,在保證產(chǎn)品質(zhì)量的同時,還配有扎實的售后技術咨詢和服務,歡迎來電咨詢!
詳情介紹:
中文名稱:兔抗PTPN6(Ab-564) 多克隆抗體 

英文名稱: Anti-PTPN6(Ab-564) rabbit polyclonal antibody

別      名: MSK1; RLPK; MSPK1

相關類別: 一抗

儲       存: 冷凍(-20℃) 避光

宿       主: Rabbit

抗       原: PTPN6(Ab-564)

反應種屬: Human

標 記 物: Unconjugate

克隆類型: Unconjugate

技術規(guī)格

Background:

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.

Applications:

WB

Name of antibody:

PTPN6(Ab-564)

Immunogen:

Synthesized peptide derived from C-terminal of human SHP-1.

Full name:

ribosomal protein S6 kinase, 90kDa, polypeptide 5

Synonyms:

MSK1; RLPK; MSPK1

SwissProt:

O75582

WB Predicted band size:

90 kDa

WB Positive control:

Jurkat cells lysate

WB Recommended dilution:

500-3000





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